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Join Chesterfield-based Fleet Feet Sports and McBride and Son Homes, two of the sponsors for Relay and Run for 21, held annually to raise money for Down Syndrome Association of Greater St. Louis and Dads Appreciating Down Syndrome Community Outreach Fund. Routes consist of three loops, all within Clayton and University City areas. Contact 314.961.2504 or abby@dsagsl.org. 7:30 a.m. RunFor21K.com